User blog comment:Kogath/Monster Hunter X Discussion/@comment-26836109-20150929192203/@comment-25275196-20151002000808

I don't think so, it's confirmed that Dino is the first of the E4 that you face, and I definitely think that you'll be able to kill it then. Remember how you fought Gore several times in 4, but you kept going at him non-stop until he was dead. If you do encounter Dino early on, like in previous games, he will be a thorn in your side until you finally kill him. Just because Dino looks strong and all the emphasis is placed on him does not mean he's the strongest, after all, they said themself that the whole E4 is equal in strength.

Personally, What I think will happen is:

You start in Beruna, everything happens as normal in MH games all the way up to the level of "decently hard, but not UOP", which you get Dino as an urgent. As soon as you defeat him, you unlock 3 urgents, for each of the other flagships. When you defeat Raizex, you unlock Kokoto, When you defeat Gamuto, you unlock Pokke. Tama unlocks Yukumo. As soon as you have defeated all 4, you get one final urgent, which will be the final boss, presumably a dragon elemental. After that, you get the urgent for high rank, Yay!